Without lowering, my opinion is you will be fine.
With a lowered height, it will be ify.
I am lowered 1.25" with neuspeed springs, running OZ Ultraleggeras (18x8 et45), and I had a slight rub in the front (only) which turned out to be the top screw for the wheel well liner. After I removed that fastener, no rubbing, but keep in mind you will be pushed out another 5 mm, and that may end up rubbing.
Unless you plan on rolling/modifying fender/fender liners, in my humble opinion, I would stick with 18x8 with a max offset of ET45.
Oh by the way, I'm running 225/40/18 Michelin Pilot Sport PS2 rubber.